嗜酸性食管炎

定义

嗜酸性食管炎 involves a buildup of a specific type of white blood cells, 被称为嗜酸性粒细胞, in the lining of your esophagus. The esophagus is the tube that carries food from your mouth to your stomach. The buildup of eosinophils is due to a reaction to foods, allergens, or acid reflux.

原因

The exact cause of eosinophilic esophagitis is not known. It is believed that an immune reaction to certain foods leads to a buildup of eosinophils. As a result, the lining of the esophagus becomes swollen and inflamed.

Most people with this disorder have a family or personal history of allergies or asthma. Triggers such as mold, pollen, and dust mites may also play a role.

症状

嗜酸性食管炎 can affect both children and adults.

症状 in children include:

• 进食问题
• 腹部疼痛
• 呕吐
• 吞咽困难
• Food getting stuck in the esophagus
• Poor weight gain or weight loss, poor growth, and malnutrition

症状 in adults include:

• Food getting stuck when swallowing (dysphagia)
• 胸部疼痛
• 胃灼热
• 上腹部疼痛
• Backflow of undigested food (regurgitation)
• Reflux in the esophagus that does not get better with medicine

考试和测试

Your health care provider will take a detailed history and perform a physical exam. This is done to check for food allergies and to rule out other conditions, such as gastroesophageal reflux disease (GERD).

Tests that may be done include:

• 血液测试
• 过敏皮肤试验
• 胃镜检查
• 活组织检查 of the lining of the esophagus

治疗

There is no cure and no specific treatment for eosinophilic esophagitis. 治疗 involves managing your diet and taking medicines.

If you test positive for food allergies, you may be told to avoid those foods. Or you may avoid all foods that are known to trigger this problem. Common foods to avoid include seafood, eggs, nuts, soy, wheat, and dairy. Allergy testing may discover specific foods to avoid.

Proton pump inhibitors can help control symptoms, but they don't help the problem causing symptoms.

Your provider may prescribe topical steroids taken orally or inhaled. You also may take oral steroids for a short time. Topical steroids don't have the same side effects as oral steroids.

If you develop narrowing or strictures, a procedure to open up or dilate the area may be needed.

You and your provider will work together to find a treatment plan that works best for you.

支持团体

支持团体，例如 American 合作伙伴hip for Eosinophilic Disorders can help you understand more about eosinophilic esophagitis. You can also learn ways to manage your condition and cope with the disease.

前景(预测)

嗜酸性食管炎 is long-term (chronic) disease that comes and goes over a person's lifetime.

可能出现的并发症

Possible complications may include:

• Narrowing of the esophagus (a stricture)
• Food getting stuck in the esophagus (common in both children and adults)
• Severe swelling and irritation of the esophagus

When to Contact a Medical Professional

Contact your provider if you have symptoms of eosinophilic esophagitis.

参考文献

福尔克GW，卡兹卡DA. 食道疾病. In: Goldman L, Schafer AI, eds. Goldman-Cecil医学. 26日艾德. Philadelphia, PA: Elsevier; 2020:chap 129.

Hirano I, Chan ES, Rank MA, et al. on behalf of the AGA Institute Clinical Guidelines Committee and the Joint Task Force on Allergy-Immunology Practice Parameters. AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters Clinical Guidelines for the Management of Eosinophilic Esophagitis. 胃肠病学. 2020;158(6):1776-1786. pubmed.ncbi.nlm.国家卫生研究院.gov / 32359562 /.

汗的年代. 嗜酸性食管炎, pill esophagitis, and infective esophagitis. 在:Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21艾德. Philadelphia, PA: Elsevier; 2020:chap 350.